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KMID : 0358820110380020135
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Journal of Korean Society of Plastic and Reconstructive Surgeons
2011 Volume.38 No. 2 p.135 ~ p.142
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Comparative Study for Compatibility of Acellular Dermis (SureDerm™) and Synthetic Material (PROCEED®) on Abdominal Wall Defect in Rabbit Models
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Kang Nak-Heon
Song Seung-Han
Kang Dae-Young
Ahn Jae-Hyoung
Choi Da-Mi
Kim Jin-Young
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Abstract
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Purpose: Deficiencies of the abdominal wall can be the a result of infection, surgery, trauma, or primary herniation. For abdominal wall reconstruction, synthetic materials have been shown to provide a better long-term success rate than primary fascial repair. But, synthetic materials cannot elicit angiogenesis or produce growth factor and are therefore plagued by an inability to clear infection. As a result of the inherent drawbacks of synthetic, significant effort has been spent on the identification of new bioprosthetic materials. The aim of our study is to evaluate the effectiveness of a synthetic material (PROCEED®) and an ADM (SureDerm™) to repair abdominal wall defects in a rabbit models.
Methods: We measured the tensile strength of the SureDerm™ and PROCEED® by a Tension meter (Instron 4482). 16 Rabbit models were assigned to this study for abdominal wall reconstruction. Abdominal defect of 8 rabbits were reconstructed by PROCEED® and the rest were reconstructed by SureDerm™. We assessed gross and histologic examinations for the reconstructed abdominal wall.
Results: The tensile strength of SureDerm™ and Gore Tex® is 14.64±0.51Mpa, 8.54±0.45Mpa. PROCEED® was estimated above the limits of measurement. Inflammatory reaction of PROCEED® persisted for 32weeks, but SureDerm™ decreased after 16weeks. Vascular ingrowth into the SureDerm™ was seen after 32 weeks. The basement membrane of SureDerm™ changed into a form of pseudoperitoneum. In PROCEED®, it seemed like pseudoepithelial lining was made from the fibrosis around the mesh.
Conclusion: In our study, the SureDerm™ not only have less inflammatory reaction and presented more angiogenesis than the PROCEED®, but also have pseudoperitoneum formation. It is expected that SureDerm™ is useful for abdominal wall reconstruction. However, a long-term study of its usage consequences are thought to be needed.
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KEYWORD
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Abdominal wall defect, Acellular dermis, Synthetic material
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